Positron Emission Tomography (PET) Scan, PET/CT & Vitamin B-12

Positron emission tomography (PET) scan which can be used in the diagnosis of cancer, is a non-invasive nuclear medicine procedure that involves the injection of a small radiopharmaceutical (FDG), a glucose analog, into the body. The glucose within the substance is metabolized more rapidly in areas of malignant lesions thus causing an increased reuptake of the chemical. However, because the FDG cannot be metabolized and is essentially trapped within the cell, areas of malignancy appear as “hot spots” when the body is scanned by the circular array of detectors in the actual PET scanner. The results are based on the intensity of the FDG levels within a suspicious region in relation to the FDG level in a certain volume of tissue, the amount of the injected dose and the patient’s body weight.

Because the PET scan provides metabolic diagnostics unlike other radiologic diagnostic studies such as the traditionally used mammogram, CT and MRI, it affords earlier detection of malignancy, differentiation of benign vs. malignant lesions, the detection of metastatic disease in normal-size lymph nodes and the assessment of early tumor treatment efficacy. Until now, the PET scan has not been rapidly integrated into popular medicine due to its $1 million to $2.5 million machine cost. Hospital CAT scan and MRI procedures cost $1100 and $1500 respectively, compared to a PET scan fee of $3000. Recent approval by Medicare in 2002 may affect the cost effectiveness for hospitals’ use of the PET scan.

Stanford Hospital and clinics now have a powerful new diagnostic imaging system known as PET/CT. This hybrid technology combines the strengths of two well-established imaging modalities in one imaging session to more accurately diagnose and locate cancers while increasing patient comfort. Clinical research has shown that in comparison to a PET scan alone, PET/CT technology provides new information that can alter a patient’s treatment plan to better target the cancer in approximately one-third of the cases. It is particularly useful in cancers of the head and neck, lung, colon, thyroid and breast, along with lymphoma and melanoma. A PET/CT scan is non-invasive, painless and takes about 30 minutes. Private insurance and Medicare cover the procedure. Stanford physicians will use the scanner to detect and stage cancers and also to monitor patients’ response to treatment. “This scanner combines the best of PET with the best of CT and the sum of the two is clearly greater than its parts,” Said Robert Herfkens, MD, Professor of Radiology.

Similar in concept to the PET Scan, is a new technique for detecting cancerous tumors using vitamin B-12 developed by researchers from the University and the Mayo Clinic in Rochester, Minn. The researchers, Dr. Doug Collins, from the Mayo Clinic, and Dr. Harry Hogenkamp, a University biochemist and professor, injected a vitamin B-12 compound with radioactive atoms attached to them into patients. Although all cells require B-12, cancer cells consume much greater quantities because of their aggressive growing nature. Using an imaging device similar to a CT scan, doctors can determine where concentrations of the B-12 exist, thus indicating a malignant growth. Although this technique must still undergo widespread testing and approval, it shows promising results in its ability to detect tumors in dense breast tissue and could be effective in discovering breast tumors that mammograms fail to detect. In addition, the researchers are exploring ways to use vitamin B-12 as a conduit in destroying malignant tumors. “Vitamin B-12 will act like the Trojan Horse. Tumors will need it, but there will be a lethal substance on the back,” explained Dr. Collins.

Spring 2003



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